Medinfo - Find - Donald Novak

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Faculty, Pediatrics, HSC Teaching Faculty


Complete Name: Donald A Novak, M.D.

Phones:UF Business Telephone: (352) 273-9350

Postal:UF Business Mailing
    Po Box 100296
    Gainesville, FL 326100296

Relationships:

Education:

Medical School
University of South Florida

Internship
Baylor College of Medicine
Pediatrics

Residency
University of South Florida
Pediatrics

Fellowship
Cincinnati Children's Hospital
Pediatrics



Publications:
  • Pushpa V. Thadani, PhD,Jerome F. Strauss, III, MD, PhD, Sudhansu K. Dey, PhD,Virginia M. Anderson, MD,Kenneth L. Audus, PhD,Karen S. Coats, PhD, James C. Cross, DVM, PhD,Adrian Erlebacher, MD, PhD,Vadivel Ganapathy, PhD,Daniel I. Linzer, PhD, Richard K. Miller, PhD, Donald A. Novak, MD,Rao S. Rapaka, PhD,Yoel Sadovsky, MD,Carolyn M. Salafia, MD, Michael Soares, PhD,Jashvant Unadkat, PhD (2004) NIDA Conference Report on Placental Proteins, Drug Transport and Fetal Development.  Am J Obstet Gynecol. 191(6):1858-62.
  • Novak, D., Quiggle, F., Matthews, J. (2004) Androgen secretion by Rcho-1 cells is independent of extracellular glutamate concentration.  Placenta.  25(6):548-52.
  • Regnault TR, Marconi AM, Smith CH, Glazier JD, Novak DA, Sibley CP, Jansson T. (2005) Placental amino acid transport systems and fetal growth restriction--a workshop report.  Placenta. 26 Suppl A:S76-80.
  • Novak,D., Quiggle,F., & Haafiz,A.(2006) Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells. Biochimie, 88(1) 39-44.
  • Novak,D.A., Lehman,M., Bernstein,H., Beveridge,M.J., & Cramer,S.D. (2006) SNAT expression in rat placenta. Placenta.27: 510-516. 
  • Davis MK, Andres JM, Jolley CD, Novak DA, Haafiz AB, González-Peralta RP. (2007) Antibodies to Escherichia coli outer membrane porin C in the absence of anti-Saccharomyces cerevisiae antibodies and anti-neutrophil cytoplasmic antibodies are an unreliable marker of Crohn disease and ulcerative colitis. J Pediatr Gastroenterol Nutr.  Oct;45(4):409-13.
  • Adewumi AO, Ashoor IF, Soares FM, Guelmann M, Novak DA.(2010) Eruption hematoma as a possible oral sign of infantile scurvy.  Pediatr Dent  Mar-Apr;32(2):151-5.
  • Allah Haafiz, Hilton M. Bernstein, Mark Beveridge, Donald A. Novak (2010) Both Genders Can Propagate Obesity-Prone-Phenotype Impacting Placental Amino Acid Transport System A Activity in a Rat Model of Gestational Protein Restriction Adv Clin Exp Med 2010, 19, 2, 00–00
  • Haafiz Allah, Yuan-Xiang Pan, Donald Novak (2011) Placental amino acid transport system A: an assessment of SNAT1 and SNAT2 expression in F1 and F2 placentas in a rat model of gestational protein restriction.  In Press Advances in Clinical and Experimental Medicine
  • Christian Farrington, Don Novak, Chen Liu, Allah B Haafiz  (2010) Immunohistochemical localization of transforming growth factor β-1 and its relationshipwith collagen expression in advanced liver fibrosis due to biliary atresia Clinical and Experimental Gastroenterology Dec, 2010
  • Allah Haafiz MD1*, Jonathan Williams MD2, Joel Andres MD1 , Don Novak MD1  (2011) A newborn liver mass that never existed: a somber reminder of embryonic ties between umbilical vein and portal venous system. In Press Hepatic Medicine: Evidence and Research
  • Jaclyn L. Otero1, Regino P. González-Peralta2, Joel M. Andres2, Christopher D. Jolley2, Don A. Novak2 and Allah Haafiz2 (2011)  Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a “Wait and See” Approach is Optimal Clinical Medicine Insights: Pediatrics.

Research:

Pediatric gastroenterologist Donald Novak seeks to better understand whether fetal nutrition plays a role in the origin of certain diseases that surface in adulthood.

As alarm rises over soaring rates of obesity, diabetes and high blood pressure, scientists are eager to determine whether nature or nurture, or some combination, spurs development of these conditions.

“There are many people around the world who don’t have enough protein in their diets, and malnutrition is a major cause of babies being born small around the world,” says Novak, a professor with the division of pediatric gastroenterology at UF?s College of Medicine. “There is a lot of evidence that when infants are born small, compared to their counterparts, they have a higher risk of these specific disorders.”

One possible answer: What mothers eat when they are pregnant could alter the function of key genes in their offspring, even without changing the genes? fundamental DNA sequence.

Novak and his colleagues have found from ongoing animal studies that a high-protein maternal diet predisposes offspring to health problems such as insulin resistance in adulthood, a precursor to diabetes. Other findings show that protein deprivation during pregnancy also is linked to the development of larger body type in rats, a tendency that persisted for two generations.

The work of UF researchers and others also raises questions about standard care of premature babies and newborns whose growth in the womb was retarded. The suggested protein intake for these infants is relatively high, to help spur “catch-up” growth. In addition, babies who are fed formula tend to take in higher protein levels than those who are fed breast milk.

Metabolic syndrome is a major public health problem characterized by a combination of abdominal obesity, high blood pressure and insulin resistance. Novak and his colleagues are looking at how maternal diet might alter gene function and influence the transmission of disease to subsequent generations.

“Genes are tightly wound around proteins; if those proteins are altered in certain ways, it’s more difficult for the gene to be active or for new proteins to be made from the gene,” Novak says.


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