Medinfo - Find - Regino P Gonzalez-Peralta
 
 

Faculty, Pediatrics, Medicine


Complete Name: Regino Primitivo Gonzalez-Peralta, M.D.

Phones:UF Business Telephone: (352) 273-9350

Postal:UF Business Mailing
    Po Box 100296
    Gainesville, FL 326100296

Relationships:

Education:

Medical School
Universidad Central del Este
Dominican Republic

Residency
Cook County Children’s Hospital
Pediatrics

Residency
University of Florida
Pediatrics

Fellowship
University of Florida
Pediatric Gastroenterology 


Publications:
  • RP Gonzalez-Peralta, DA Kelly, B Haber, JP Molleston, KF Murray, MM Jonas, M Shelton, G Mieli-Vergani, Y Lurie, S Martin, T Lang, A Baczkowski, M Geffner, S Gupta, M Laughlin for the International Pediatric Hepatitis C Therapy Group.Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics. Hepatology 2005;42:1010-8.
  • CJ Jolley, RP Gonzalez-Peralta. Hepatitis C. In: Walker WA, Goulet OJ, Kleinman RE, Sanderson IR, Sherman PM, Shneider BL (eds), Pediatric Gastrointestinal Disease:5th Edition, Hamilton, Ontario, BC Decker, 2008:847-58.
  • A Delgado-Borrego, SH Jordan, B Negre, RP Gonzalez-Peralta. Hepatitis C en niños. In C Velasco (ed). Temas selectos de Hepatología, Gastrohnup Ltda. Editorial, 2008.
  • U Shah, D Kelly, MH Chang, T Fujisawa, S Heller, RP Gonzalez-Peralta, P Jara, G Mieli-Vergani, N Mohan, KF Murray, KF Murray. Management of chronic hepatitis B in children. Journal of Pediatric Gastroenterology and Nutrition 2009;48:399-404.
  • RP Gonzalez-Peralta, MR Langham, JM Andres, P Mohan, PM Colombani, MK Alford, KB Schwarz. Hepatocellular carcinoma in two young adolescents with chronic hepatitis C. Journal of Pediatric Gastroenterology and Nutrition 2009;48:630-5.
  • JR. Rodrigue, W Balistreri, B Haber, MM Jonas, P Mohan, JP Molleston, KF Murray, MR Narkewicz, P Rosenthal, LJ Smith, KB Schwarz, P Robuck, B Barton, RP Gonzalez-Peralta. Impact of Hepatitis C Virus Infection on Children and their Caregivers: Quality of Life, Cognitive, and Emotional Outcomes. Journal of Pediatric Gastroenterology and Nutrition 2009;48:341-7.
  • N Mohan, RP Gonzalez-Peralta, T Fujisawa, MH Chang, S Heller, P Jara, D Kelly, G Mieli-Vergani, U Shah, KF Murray. Chronic hepatitis C virus infection in children. Journal of Pediatric Gastroenterology and Nutrition 2010;50:123-31.
  • Schwarz KB, RP Gonzalez-Peralta, Murray K, Molleston J, Haber B, Jonas M,  Mohan P, Balistreri W, Rosenthal P, Narkewicz M, Smith L, Robuck P, and Barton B for the PEDS-C Clinical Research Network. Peginterferon with or without Ribavirin for chronic hepatitis C in children and adolescents: final results of the PEDS-C Trial. Gastroenterology 2011;140:450-8.
  • JR Rodrigue, W Balistreri, B Haber, MM Jonas, P Mohan, JP Molleston, KF Murray, MR Narkewicz, P Rosenthal, LJ Smith, SJ Lobritto, KB Schwarz, PR Robuck, B Barton, RP Gonzalez-Peralta. Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/emotional, and cognitive outcomes in children. Hepatology 2011;53:1468-75.
  • A Delgado-Borrego, L Smith, MM Jonas, CA Hall, B Negre, M Ogrodowiczc, R Raza, SH Jordan, DA Ludwig, T Miller, SE Lipshultz, RP Gonzalez-Peralta, RT Chung. Expected and actual case ascertainment and treatment rates for Hepatitis C-infected children in Florida and the US: epidemiological evidence from statewide and nationwide surveys. Journal of Pediatrics (in press).
  • CL Mack, RP Gonzalez-Peralta, N Gupta, D Leung, MR Narkewicz, EA Roberts, P Rosenthal, KB Schwarz. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition practice guidelines: diagnosis and management of Hepatitis C infection in infants, children and adolescents. Journal of Pediatric Gastroenterology and Nutrition (in press).

Research:

Dr. Gonzalez-Peralta's academic pursuits are focused on developing a research and clinical program in Pediatric Hepatology. His initial laboratory work defined the importance of immune-mediated mechanisms in the pathogenesis of liver-cell damage in chronic hepatitis C. His laboratory also developed a novel technique to study HCV heterogeneity (quasispecies) based on single-strand conformational polymorphism. Using this technique, his group was one of the first to demonstrate that HCV heterogeneity played an important role in the pathobiology of this viral infection, particularly as it pertained to treatment response. Despite progress of the understanding of the molecular biology of HCV infection, it became apparent that the study of HCV replication and pathogenesis was hampered by a lack of a suitable animal or in vitro model of viral infection. Thus, his laboratory then focused on developing an efficient cell culture model of HCV replication, with financial support from the NIH, University of Florida and the Blowitz-Ridgeway Foundation. Although Dr. Gonzalez-Peralta derived very encouraging preliminary results in the research laboratory, he began to ‘miss’ the interactions with his patients and their families. Accordingly, as a way to reconcile personal and academic-research interests, Dr. Gonzalez-Peralta became actively involved in studying the clinical impact of HCV infection in children. With support from the pharmaceutical industry and NIH, he has participated in several investigator-initiated and industry-sponsored trials of interferon and pegylated interferon alone or with ribavirin. Through the participation in the NIH-sponsored PEDS-C consortium, his group spearheaded pivotal studies assessing the effects of HCV infection and antiviral therapy on the quality of life of children infected with this virus. More recently he has also focused on studying hepatitis B virus (HBV) infection in children. He is actively involved in trials assessing pharmacokinetic, safety, and efficacy of nucleos(t)ide in children with chronic HBV infection. In addition, his team has been an active member in the Studies for Liver Transplantation (SPLIT), a consortium of North American centers that prospectively tracks the outcome of children who need (and undergo) liver replacement.

  • Childhood HBV and HCV infection
  • Pediatric Liver Transplantation
  • Alpha 1 Antitrypsin Deficiency
  • Wilson’s Disease
  • Clinical Trials
  • Gastroenterology
  • Hepatology
  • Liver transplant

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